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Oxford scientist says its vaccine is making headway, could show efficacy by June

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British scientists developing a potential vaccine for the coronavirus hope to see a “signal” as to whether their vaccine candidate is working by June, one official involved in the effort told “Meet the Press” Sunday. Sir John Bell, the Regius Professor of Medicine at Oxford University, where one of the leading efforts to develop a vaccine is underway, said that the prospects for its candidate are “pretty good” and that “as every day goes by, the likelihood of success goes up.” The researchers hope to have enough data from their phase-two trials that “we would get evidence that the vaccine has efficacy by the beginning of June.”

The group at Oxford is one of the many racing toward finding an effective and safe vaccine for the coronavirus alongside efforts to contain the spread of the pandemic. More than 230,000 people have died of the coronavirus since January, and there have been more than 3.3 million reported coronavirus cases around the world, according to NBC News. Bell did not offer any timeline for when a vaccine might be fully developed but said that in the rush toward …

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The Human Immune System Explained – Why Shelter-In-Place Is The Absolute Worst Thing For Your Immune System.

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Definition of the Immune System:

Immunity is the capability of multicellular organisms to resist harmful microorganisms from entering it. Immunity involves both specific and nonspecific components. The nonspecific components act as barriers or eliminators of a wide range of pathogens irrespective of their antigenic make-up. Other components of the immune system adapt themselves to each new disease encountered and can generate pathogen-specific immunity.[1]

An immune system may contain innate and adaptive components. The innate system in mammalians, for example, is composed of primitive bone marrow cells that are programmed to recognize foreign substances and to react. The adaptive system is composed of more advanced lymphatic cells that are programmed to recognize self-substances and not to react. The reaction to foreign substances is etymologically described as inflammation, meaning to set on fire. The non-reaction to self substances is described as immunity, meaning to exempt or as immunotolerance. These two components of the immune system create a dynamic biological environment where “health” can be seen as a physical state where the self is immunologically spared, and what is foreign is inflammatorily and immunologically eliminated. “Disease” can arise when what is foreign cannot be eliminated or what is self is not spared.

Innate immunity, also called native immunity, exists by virtue of an organism’s constitution, that is its genetic make-up, without external stimulation or a previous infection. It is divided into two types: (a) Non-Specific innate immunity, a degree of resistance to all infections in general. (b) Specific innate immunity, a resistance to a particular kind of microorganism only. As a result, some races, particularly individuals or breeds in agriculture do not suffer from certain infectious diseases.

Adaptive immunity can be sub-divided depending on how the immunity was introduced in ‘naturally acquired’ through chance contact with a disease-causing agent, whereas ‘artificially acquired immunity’ develops through deliberate actions such as vaccination. Both naturally and artificially acquired immunity can be further subdivided depending on whether the host built up immunity itself by antigen as ‘active immunity’ and lasts long-term, sometimes lifelong. ‘Passive immunity’ is acquired through transfer (injection or infusion) of antibodies or activated T-cells from an immune host; it is short-lived—usually lasting only a few months. The diagram below summarizes these divisions of immunity.

Immunity.png

Adaptive immunity can also be divided by the type of immune mediators involved; humoral immunity is the aspect of immunity that is mediated by secreted antibodies, whereas cell-mediated immunity involves T-lymphocytes alone. Humoral immunity is called active when the organism generates its antibodies, and passive when antibodies are transferred between individuals or species. Similarly, cell-mediated immunity is active when the organisms’ T-cells are stimulated, and passive when T cells come from another organism.[2]

ATTRIBUTION: Wikipedia contributors. “Immunity (medical).” Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, 30 Apr. 2020. Web.

The human immune system is not isolated to the human being. This statement means that the human immune system is tied to all other systems the human being is in contact with. The keyword in all this is contact.

The human immune system is an evolved system. It is very complex due to the extreme amount of time that has gone into its formation. From the first bacteria to the first viruses that marshaled those bacteria into organized groups that utilized the surrounding minerals and vitamins and enzymes to form the first single-celled animals to the apex creatures all over this planet, humans have inherited a biological gift that allows their existence in the midst of all that is not human. The same goes for every creature alive no matter how big or small.

When one figures in the entirety of the Universe and concepts like panspermia, which is the concept that the compounds and chemicals that are essential for life are spread throughout the Universe by hitchhiking on asteroids and comets, one begins to see that the concept of immunity involves contact with the entire Universe and is a very broad concept indeed.

In the course of the development of the human immune system, various compounds, chemicals, enzymes, and minerals have become essential to its formation. Without these compounds, the human immune system ceases to function and the entirety of contact with the surrounding world becomes untenable, in fact, necessarily avoidable.

We see this in Acquired Immune Deficiency Syndrome patients and also in patients who have had their immune system ravaged by chemotherapy in an attempt to rid the body of cancer. Often in these cases is it necessary to require extreme measures to isolate these patients from foreign elements such that they do not overwhelm the compromised immune system of the individual. This is a form of shelter in place humanity is already very familiar with and which provides ample case study material on what happens to the human immune system when it is isolated from the basic requirement of contact.

Without contact, the human immune system is purposeless and has no stimulation. When it is without stimulation for long enough, it becomes weak and ultimately becomes vestigial (a useless remnant of a once vibrant system). Vestigial systems rarely resuscitate. Instead, they remain vestigial and useless. A huge effort is required to bring them out of biological slumber. Such resuscitation is very hard but it is not impossible.

Required elements for the human immune system include but are not limited to:

  1. Exposure to antigens – this can come from dirt, air, water, other humans, animals, and plants, and food.
  2. Vitamin D3 – this can come from only one place for humans, sunlight. One can take a supplement, but supplements are not renewable.
  3. Clean water – in order to have clean water one must understand what is in the water they drink, mostly municipal tap water, well water, naturally occuring surface standing fresh water, or rainfall. Some entities (biological and non-biological) in the water are tolerable and desirable for consumption and others are not. Knowing what they are is possible for humans now through scientific study. This leads to humans have the capability to remove such harmful substances from water and render it clean worldwide.
  4. Restful sleep – in order to attain deep sleep, which the body must have to replenish itself – including the immune system and its requirements, the body has to be conditioned to enter into deep sleep. This requires a pattern where the body builds up to being able to deliver the required elements for deep sleep rejuvination. Without this pattern and build up, deep sleep is not attainable. In other words, restful deep sleep is a process, not just an isolated activity.
  5. Mental Health – perhaps an overlooked requirement for a strong immune system is mental health. Without proper sleep, nutrition, hydration, interaction, and a sense of purpose, the human mind withers and dies. This effects the brain structure and chemistry producing a permanent and uncureable state of dysfunction in the brain. It is a physical impairment that has mental consequences. It is an actual physical disease as it is tied to the physical functioning of the brain. The mind and the brain are one entity. Isolation is a severe form of torture for the human brain. Every function of the human brain requires, indeed craves, stimulation from the five senses. Without this stimulation mental health is not sustainable and a return to mental health, as long as it is not chronic and irreparable, requires stimulation, not overstimulation, and the stimulation must be of a positive nature contributing to the well being of the entire human system which that particular mind is a part of. It is also important for that particular mind to be surrounded by other minds that have the same vibrant mental health such that a group mind is formed that supports the attainments of the individual minds.

There may indeed be more required elements and there most likely are. One can most surely encounter them when reading a wide variety of wisdom from a wider variety of sources, mainstream and not. These would be deemed the essential or emergency elements of a healthy functioning immune system. The critical immediately needed elements. Of course, long term chronic depletion of things such as trace minerals will eventually lead to a state of collapse as well. The elements listed here are the ones that can be most effectual in leading to the immune system collapse in a number of days rather than in some cases years from the less critical build-up (tertiary) causes. Here is a really great video series by Ninja Nerd Science. View some or all of these for a good overview of immunity and how it works.

Shelter in place and how it may be the most devastating state of being possible for the human immune system.

The Coronavirus/COVID19 Crisis Response has brought the entire world to a state of house arrest or Shelter In Place as it is known in most explanations. We have discussed earlier that the human immune system requires elements that are not easily acquired in an indoor and isolated place.  If the Shelter In Place order goes on for long enough, all of the major critical required elements of the human immune system will be shattered, and perhaps permanently.  Return to normal human activity will result in a massive spike in disease transmission (most of it NOT COVID19 AT ALL BUT LISTED AS COVID19 IN ORDER TO SECURE FEDERAL FUNDING FOR RELIEF FROM THE EFFECTS OF THE SHELTER IN PLACE).  We are already seeing numbers inflated by morgues and city governments seeking such funding.  This is a dangerous dangerous trend that we are seeing happening and it literally has never happened like this before in all of history.  At least not in terms of a medical emergency.

Shelter In Place is the absolute worst-case scenario for the human immune system and needs to be ended.  One place to keep an eye on is Sweden.  The Swedish government decided on herd immunity rather than Shelter In Place and a shot.  So far, even though they have had a larger percentage of people die from the virus, their curve flattened out tremendously and very quickly afterward and it is anticipated that their economy and their second and third waves will be significantly less impacted by the inevitable return of the virus.

The argument that Shelter In Place does not need to happen in any place other than very densely populated centers is a very strong argument indeed.  Not only does one size fits all medicine, a shot, apply in this case to healthy people with no need to fear COVID19, but one size fits all responses also do not need to be applied.  In cities less than 1 million, it is entirely plausible that there would be very little impact from COVID19.

This could be the start of another article on the need to reassess living in large cities and the need for decentralization.  But it certainly bears at least a mention in this article.  The idea that humans have to be so centralized is beginning to be less and less true.  With technology the way it is and remote work becoming more and more a reality in life, there is every indication that our society could adapt quite well to decentralization.

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