Are high-protein total diet replacements the key to maintaining healthy weight?

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IMAGE: Overview of the experimental protocol (A) and variables assessed during each 32-h test (B). CON, control diet; EE, energy expenditure; HP-TDR, high-protein total diet replacement; N/A, not applicable; REE, resting…
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Credit: The Authors

Key Points
High-protein total diet replacement products are widely available to consumers; however, their efficacy has not been adequately studied.
AJCN study compared the impact of a high-protein total diet replacement to that of a typical North American diet on key components of energy metabolism.
The high-protein total diet replacement compared to the North American diet resulted in higher energy expenditure, increased fat oxidation and negative fat balance, likely implying body fat loss.
Diets with a higher proportion of protein might offer a metabolic advantage compared to a diet consisting of the same number of calories, but with a lower proportion of protein.
Future studies are needed to better understand the long-term effects of high-protein total diet replacements on both healthy and diseased population groups.
Rockville, MD According to the World Health Organization, obesity has nearly tripled worldwide since 1975. In 2016, for example, more than 1.9 billion adults were categorized as overweight. Of these, more than 650 million had obesity. Because obesity is associated with a higher incidence of diabetes, cardiovascular disease and some cancers, the rise in its incidence has led to a global public health emergency.
Total diet replacements, nutritionally complete formula foods designed to replace the whole diet for a set period of time, have become increasingly popular strategies to combat obesity. Another …

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